Same issues, apparently random freezes that also affect the mouse cursor so the game can't be closed or restarted normally. Rather than sign out or force a system shutdown, I usually CTRL-ALT-DEL from GW2, select Task Manager, ALT-TAB to focus it, TAB and arrow keys to highlight the GW2 task and ALT-E to end it, after which the game can be restarted as usual. ASUS G74SX gaming notebook (NVidia GTX 560m), so gfx settings are fairly low.